| 3. Jornada | 15.08.2021 | Werder Bremen | - | SC Paderborn 07 | 1:4 | ||||
| 5. Jornada | 29.08.2021 | Dynamo Dresden | - | SC Paderborn 07 | 0:3 | ||||
| 6. Jornada | 12.09.2021 | SC Paderborn 07 | - | Schalke | 0:1 | ||||
| 12. Jornada | 31.10.2021 | Karlsruher SC | - | SC Paderborn 07 | 2:4 | ||||
| 15. Jornada | 28.11.2021 | SC Paderborn 07 | - | Hansa Rostock | 1:1 | ||||
| 17. Jornada | 11.12.2021 | SC Paderborn 07 | - | Darmstadt | 0:1 | ||||
| 25. Jornada | 04.03.2022 | Holstein Kiel | - | SC Paderborn 07 | 3:4 | ||||
| 31. Jornada | 24.04.2022 | SC Paderborn 07 | - | Hannover | 3:0 |  |
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| 32. Jornada | 30.04.2022 | Hansa Rostock | - | SC Paderborn 07 | 0:0 | ||||
| 34. Jornada | 15.05.2022 | Darmstadt | - | SC Paderborn 07 | 3:0 |
Ghana