| 1. Jornada | 13.08.2021 | Gudja United | - | Sirens FC | 0:1 |  |
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| 2. Jornada | 20.08.2021 | Sirens FC | - | Mosta FC | 1:1 | |
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| 3. Jornada | 12.09.2021 | Sirens FC | - | Hibernians FC | 1:3 | ||||
| 4. Jornada | 18.09.2021 | St. Luċija FC | - | Sirens FC | 1:3 | |
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| 5. Jornada | 26.09.2021 | Sirens FC | - | Sliema Wanderers | 2:2 | ||||
| 6. Jornada | 17.10.2021 | Valletta FC | - | Sirens FC | 3:1 | ||||
| 7. Jornada | 24.10.2021 | Sirens FC | - | Birkirkara FC | 3:2 | |
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| 9. Jornada | 21.11.2021 | Sirens FC | - | Balzan FC | 1:6 | ||||
| 10. Jornada | 27.11.2021 | Floriana FC | - | Sirens FC | 1:2 | ||||
| 11. Jornada | 04.12.2021 | Sirens FC | - | Gżira United | 1:3 | ||||
| 12. Jornada | 13.12.2021 | Sirens FC | - | Gudja United | 0:0 | ||||
| 13. Jornada | 18.12.2021 | Mosta FC | - | Sirens FC | 2:3 | |
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| 14. Jornada | 18.01.2022 | Hibernians FC | - | Sirens FC | 1:1 | |
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| 15. Jornada | 23.01.2022 | Sirens FC | - | St. Luċija FC | 2:1 | ||||
| 16. Jornada | 29.01.2022 | Sliema Wanderers | - | Sirens FC | 1:0 |
Malta
Jamaica