| 4. Jornada | 27.08.2021 | Jong Ajax | - | SBV Excelsior | 1:2 |  |
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| 5. Jornada | 13.09.2021 | Jong Ajax | - | NAC Breda | 6:3 | |
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| 9. Jornada | 01.10.2021 | Helmond Sport | - | Jong Ajax | 3:1 | ||||
| 12. Jornada | 22.10.2021 | FC Eindhoven | - | Jong Ajax | 1:3 | |
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| 14. Jornada | 05.11.2021 | VVV-Venlo | - | Jong Ajax | 1:3 | |
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| 16. Jornada | 19.11.2021 | Jong Ajax | - | FC Volendam | 4:4 | |
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| 17. Jornada | 26.11.2021 | De Graafschap | - | Jong Ajax | 1:3 | ||||
| 18. Jornada | 06.12.2021 | Jong Ajax | - | FC Emmen | 1:0 | ||||
| 26. Jornada | 11.02.2022 | SBV Excelsior | - | Jong Ajax | 6:2 | ||||
| 31. Jornada | 18.03.2022 | Jong Ajax | - | FC Eindhoven | 2:2 | ||||
| 32. Jornada | 04.04.2022 | Jong Ajax | - | TOP Oss | 4:1 | |
Países Bajos