| 1. Jornada | 01.08.2021 | Xelaju MC | - | Cobán Imperial | 3:0 | ||||
| 2. Jornada | 07.08.2021 | Cobán Imperial | - | Sololá FC | 0:0 | ||||
| 4. Jornada | 14.08.2021 | Cobán Imperial | - | Achuapa | 2:0 |  |
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| 3. Jornada | 18.08.2021 | Nueva Concepción | - | Cobán Imperial | 2:1 | |
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| 9. Jornada | 11.09.2021 | Cobán Imperial | - | Santa Lucía | 0:1 | |
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| 11. Jornada | 25.09.2021 | Cobán Imperial | - | Iztapa | 2:1 | ||||
| 12. Jornada | 02.10.2021 | Cobán Imperial | - | Xelaju MC | 1:1 | |
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| 17. Jornada | 31.10.2021 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 18. Jornada | 07.11.2021 | Antigua GFC | - | Cobán Imperial | 2:1 |
Guatemala