| 1. Jornada | 01.08.2022 | Real España | - | Lobos UPNFM | 1:0 |  |
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| 2. Jornada | 08.08.2022 | Real España | - | Motagua | 1:1 | ||||
| 3. Jornada | 10.08.2022 | Real Sociedad | - | Real España | 2:1 | ||||
| 4. Jornada | 15.08.2022 | Real España | - | Victoria | 2:1 | ||||
| 6. Jornada | 29.08.2022 | Real España | - | Marathón | 2:0 |  |
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| 7. Jornada | 01.09.2022 | Vida | - | Real España | 1:0 | ||||
| 9. Jornada | 12.09.2022 | Real España | - | Honduras Progreso | 2:0 | ||||
| 12. Jornada | 08.10.2022 | Real España | - | Real Sociedad | 1:3 | ||||
| 13. Jornada | 16.10.2022 | Victoria | - | Real España | 1:4 | ||||
| 14. Jornada | 20.10.2022 | Real España | - | Olimpia | 0:0 | ||||
| 16. Jornada | 06.11.2022 | Real España | - | Vida | 2:1 | ||||
| 18. Jornada | 19.11.2022 | Honduras Progreso | - | Real España | 0:0 |
Honduras