| 2. Jornada | 14.02.2022 | Herrera FC | - | Veraguas United | 2:0 |  |
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| 3. Jornada | 19.02.2022 | Independiente de La Chorrera | - | Herrera FC | 1:2 | ||||
| 4. Jornada | 28.02.2022 | Herrera FC | - | Atlético Chiriquí | 1:2 | ||||
| 5. Jornada | 05.03.2022 | Herrera FC | - | San Francisco FC | 0:0 | ||||
| 6. Jornada | 09.03.2022 | Herrera FC | - | Tauro FC | 0:0 | ||||
| 7. Jornada | 13.03.2022 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 9. Jornada | 27.03.2022 | Plaza Amador | - | Herrera FC | 1:1 | ||||
| 10. Jornada | 02.04.2022 | Herrera FC | - | Potros del Este | 1:2 | ||||
| 14. Jornada | 28.04.2022 | Herrera FC | - | Independiente de La Chorrera | 4:0 | ||||
| 12. Jornada | 05.05.2022 | Herrera FC | - | UD Universitario | 3:1 | |
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| 16. Jornada | 08.05.2022 | San Francisco FC | - | Herrera FC | 3:1 |
Panamá