| 1. Jornada | 18.09.2020 | Inter Playa | - | Cafessa Jalisco | 2:1 |  |
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| 2. Jornada | 27.09.2020 | Cafessa Jalisco | - | Cafetaleros de Chiapas | 3:3 | |
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| 6. Jornada | 25.10.2020 | Cafessa Jalisco | - | Club Irapuato | 4:3 | ||||
| 7. Jornada | 02.11.2020 | Club de Ciervos | - | Cafessa Jalisco | 0:5 | ||||
| 8. Jornada | 08.11.2020 | Cafessa Jalisco | - | Cañoneros Marina | 1:0 | ||||
| 9. Jornada | 15.11.2020 | Cruz Azul Hidalgo | - | Cafessa Jalisco | 0:1 | ||||
| 10. Jornada | 22.11.2020 | Cafessa Jalisco | - | CD Cuautla | 2:2 | ||||
| 11. Jornada | 29.11.2020 | Deportivo Dongu | - | Cafessa Jalisco | 0:1 | ||||
| 12. Jornada | 06.12.2020 | Cafessa Jalisco | - | Aguacateros CDU | 4:1 | ||||
| 19. Jornada | 19.02.2021 | Club Irapuato | - | Cafessa Jalisco | 0:0 | |
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| 20. Jornada | 28.02.2021 | Cafessa Jalisco | - | Club de Ciervos | 3:0 | ||||
| 21. Jornada | 05.03.2021 | Cañoneros Marina | - | Cafessa Jalisco | 2:3 | ||||
| 23. Jornada | 21.03.2021 | CD Cuautla | - | Cafessa Jalisco | 0:2 | ||||
| 24. Jornada | 01.04.2021 | Cafessa Jalisco | - | Deportivo Dongu | 1:0 | ||||
| 25. Jornada | 03.04.2021 | Aguacateros CDU | - | Cafessa Jalisco | 1:0 | ||||
| 26. Jornada | 10.04.2021 | Cafessa Jalisco | - | Pioneros de Cancún | 0:0 |
México