| 1. Jornada | 03.06.2021 | Defensor Sporting | - | Rocha | 2:1 | ||||
| 2. Jornada | 11.06.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 3. Jornada | 16.06.2021 | Albion | - | Defensor Sporting | 2:2 | ||||
| 6. Jornada | 09.07.2021 | Defensor Sporting | - | Racing | 1:4 |  |
|||
| 7. Jornada | 15.07.2021 | Villa Teresa | - | Defensor Sporting | 0:2 |  |
|||
| 8. Jornada | 22.07.2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 | |
|||
| 9. Jornada | 28.07.2021 | Uruguay Montevideo | - | Defensor Sporting | 0:2 | |
|||
| 10. Jornada | 05.08.2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 11. Jornada | 14.08.2021 | Danubio | - | Defensor Sporting | 0:1 | ||||
| 12. Jornada | 16.09.2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 19. Jornada | 02.11.2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 | ||||
| 20. Jornada | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | |
|||
| 21. Jornada | 18.11.2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | |
|||
| 22. Jornada | 24.11.2021 | Defensor Sporting | - | Danubio | 0:1 |
Uruguay
Italia