| 1. Jornada | 25.07.2021 | Leones FC | - | Orsomarso SC | 1:0 | ||||
| 2. Jornada | 31.07.2021 | Valledupar FC | - | Leones FC | 1:1 | ||||
| 3. Jornada | 10.08.2021 | Leones FC | - | Boyacá Chicó | 0:0 | ||||
| 4. Jornada | 14.08.2021 | Fortaleza FC | - | Leones FC | 3:1 | ||||
| 5. Jornada | 20.08.2021 | Leones FC | - | Real Santander | 2:1 | ||||
| 6. Jornada | 29.08.2021 | Cortuluá | - | Leones FC | 1:0 | ||||
| 7. Jornada | 04.09.2021 | Leones FC | - | Unión Magdalena | 3:0 |  |
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| 8. Jornada | 13.09.2021 | Boca Juniors de Cali | - | Leones FC | 1:5 | ||||
| 9. Jornada | 19.09.2021 | Leones FC | - | Real Cartagena | 2:0 | ||||
| 11. Jornada | 04.10.2021 | Llaneros FC | - | Leones FC | 4:3 | |
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| 15. Jornada | 30.10.2021 | Atlético FC | - | Leones FC | 1:3 |
Colombia