| 1. Jornada | 25.07.2021 | Macará | - | Guayaquil City | 0:2 |  |
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| 2. Jornada | 31.07.2021 | Guayaquil City | - | Deportivo Cuenca | 2:1 | ||||
| 3. Jornada | 08.08.2021 | Barcelona | - | Guayaquil City | 2:1 | |
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| 4. Jornada | 15.08.2021 | Guayaquil City | - | Delfín SC | 2:1 | ||||
| 5. Jornada | 22.08.2021 | Universidad Catolica | - | Guayaquil City | 1:1 | ||||
| 6. Jornada | 29.08.2021 | Guayaquil City | - | Técnico Universitario | 1:0 | ||||
| 7. Jornada | 18.09.2021 | Orense SC | - | Guayaquil City | 2:0 | |
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| 8. Jornada | 26.09.2021 | Guayaquil City | - | 9 de Octubre | 0:1 | |
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| 9. Jornada | 03.10.2021 | LDU Quito | - | Guayaquil City | 3:1 | ||||
| 10. Jornada | 16.10.2021 | Guayaquil City | - | Olmedo | 4:2 | ||||
| 11. Jornada | 24.10.2021 | Manta | - | Guayaquil City | 1:1 | ||||
| 12. Jornada | 31.10.2021 | Guayaquil City | - | Emelec | 0:1 | ||||
| 13. Jornada | 08.11.2021 | Guayaquil City | - | Independiente del Valle | 0:2 |  |
Ecuador