| 1. Jornada | 20.02.2022 | Guayaquil City | - | Deportivo Cuenca | 3:0 |  |
|||
| 2. Jornada | 26.02.2022 | Universidad Catolica | - | Guayaquil City | 1:1 | ||||
| 3. Jornada | 05.03.2022 | Emelec | - | Guayaquil City | 2:2 | ||||
| 4. Jornada | 15.03.2022 | Guayaquil City | - | Delfín SC | 1:1 |  |
|||
| 5. Jornada | 20.03.2022 | Macará | - | Guayaquil City | 2:0 | ||||
| 6. Jornada | 03.04.2022 | Guayaquil City | - | Técnico Universitario | 0:1 | |
|||
| 7. Jornada | 10.04.2022 | Independiente del Valle | - | Guayaquil City | 0:0 | ||||
| 8. Jornada | 17.04.2022 | Guayaquil City | - | Aucas | 4:0 | ||||
| 10. Jornada | 26.04.2022 | Guayaquil City | - | Cumbayá | 4:1 | |
|||
| 11. Jornada | 30.04.2022 | Mushuc Runa | - | Guayaquil City | 2:0 | ||||
| 12. Jornada | 09.05.2022 | Guayaquil City | - | Barcelona | 1:4 | ||||
| 9. Jornada | 12.05.2022 | 9 de Octubre | - | Guayaquil City | 2:2 | |
|||
| 13. Jornada | 17.05.2022 | Gualaceo SC | - | Guayaquil City | 2:1 | ||||
| 14. Jornada | 22.05.2022 | Guayaquil City | - | LDU Quito | 2:2 |
Ecuador