| 1. Jornada | 12.07.2022 | Deportivo Cuenca | - | Guayaquil City | 1:0 |  |
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| 2. Jornada | 17.07.2022 | Guayaquil City | - | Universidad Catolica | 2:0 | ||||
| 3. Jornada | 24.07.2022 | Guayaquil City | - | Emelec | 0:0 | |
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| 4. Jornada | 30.07.2022 | Delfín SC | - | Guayaquil City | 1:3 | |
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| 5. Jornada | 07.08.2022 | Guayaquil City | - | Macará | 0:0 | ||||
| 6. Jornada | 14.08.2022 | Técnico Universitario | - | Guayaquil City | 3:1 | ||||
| 7. Jornada | 23.08.2022 | Guayaquil City | - | Independiente del Valle | 0:1 | ||||
| 8. Jornada | 28.08.2022 | Aucas | - | Guayaquil City | 2:1 | ||||
| 9. Jornada | 03.09.2022 | Guayaquil City | - | 9 de Octubre | 1:1 | ||||
| 10. Jornada | 10.09.2022 | Cumbayá | - | Guayaquil City | 3:0 | ||||
| 11. Jornada | 20.09.2022 | Guayaquil City | - | Mushuc Runa | 4:1 | ||||
| 12. Jornada | 03.10.2022 | Barcelona | - | Guayaquil City | 1:1 | |
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| 13. Jornada | 09.10.2022 | Guayaquil City | - | Gualaceo SC | 1:0 | |
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| 15. Jornada | 24.10.2022 | Guayaquil City | - | Orense SC | 1:1 |
Ecuador