| 2. Jornada | 16.01.2022 | Deportivo Toluca [Sub 20] | - | Santos Laguna [Sub 20] | 4:2 |  |
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| 3. Jornada | 21.01.2022 | Mazatlán FC [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:0 | |
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| 4. Jornada | 06.02.2022 | Deportivo Toluca [Sub 20] | - | CF Monterrey [Sub 20] | 3:0 | ||||
| 5. Jornada | 12.02.2022 | Atlético San Luis [Sub 20] | - | Deportivo Toluca [Sub 20] | 4:1 | ||||
| 6. Jornada | 20.02.2022 | Deportivo Toluca [Sub 20] | - | Cruz Azul [Sub 20] | 1:1 | ||||
| 15. Jornada | 19.04.2022 | Deportivo Toluca [Sub 20] | - | FC Juárez [Sub 20] | 2:0 | ||||
| 16. Jornada | 24.04.2022 | Deportivo Toluca [Sub 20] | - | Atlas Guadalajara [Sub 20] | 2:1 |  |
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| 17. Jornada | 01.05.2022 | Club León [Sub 20] | - | Deportivo Toluca [Sub 20] | 3:1 | |
México