| 5. Jornada | 21.08.2021 | Arsenal Tula | - | Spartak Moskva | 1:1 | ||||
| 9. Jornada | 27.09.2021 | FK Ural | - | Arsenal Tula | 2:0 | ||||
| 10. Jornada | 02.10.2021 | Arsenal Tula | - | FK Khimki | 0:0 |  |
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| 11. Jornada | 16.10.2021 | Arsenal Tula | - | Zenit | 2:1 |  |
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| 12. Jornada | 23.10.2021 | FK Rostov | - | Arsenal Tula | 4:0 | ||||
| 13. Jornada | 31.10.2021 | Arsenal Tula | - | FK Sochi | 1:2 | ||||
| 14. Jornada | 06.11.2021 | Arsenal Tula | - | FK Ufa | 0:0 | ||||
| 15. Jornada | 21.11.2021 | Dinamo Moskva | - | Arsenal Tula | 5:1 | |
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| 16. Jornada | 29.11.2021 | Arsenal Tula | - | Lokomotiv Moskva | 3:1 | ||||
| 17. Jornada | 05.12.2021 | FK Khimki | - | Arsenal Tula | 1:2 | |
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| 19. Jornada | 26.02.2022 | FK Sochi | - | Arsenal Tula | 2:0 | ||||
| 20. Jornada | 06.03.2022 | Krylia Sovetov | - | Arsenal Tula | 2:2 | |
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| 21. Jornada | 12.03.2022 | Arsenal Tula | - | Dinamo Moskva | 1:4 | |
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| 22. Jornada | 19.03.2022 | Zenit | - | Arsenal Tula | 3:0 | ||||
| 23. Jornada | 02.04.2022 | Arsenal Tula | - | Akhmat Grozny | 0:0 | ||||
| 24. Jornada | 10.04.2022 | Spartak Moskva | - | Arsenal Tula | 3:0 |  |
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| 28. Jornada | 08.05.2022 | Arsenal Tula | - | FK Krasnodar | 1:1 | |
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| 29. Jornada | 14.05.2022 | FK Ufa | - | Arsenal Tula | 2:1 | |
Zambia