| 1. Jornada | 08.08.2021 | FK Renova | - | FK Skopje | 1:1 | ||||
| 2. Jornada | 15.08.2021 | FK Skopje | - | FK Bregalnica Štip | 0:0 |  |
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| 3. Jornada | 18.08.2021 | Makedonija GP | - | FK Skopje | 5:1 | ||||
| 7. Jornada | 19.09.2021 | FK Skopje | - | KF Shkëndija 79 | 0:2 | |
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| 8. Jornada | 26.09.2021 | FK Borec | - | FK Skopje | 0:2 | ||||
| 9. Jornada | 02.10.2021 | FK Skopje | - | FK AP Brera Strumica | 0:0 | ||||
| 10. Jornada | 15.10.2021 | FK Rabotnički | - | FK Skopje | 0:1 | ||||
| 11. Jornada | 24.10.2021 | FK Skopje | - | GFK Tikvesh | 2:1 | ||||
| 12. Jornada | 30.10.2021 | FK Skopje | - | FK Renova | 0:0 | ||||
| 13. Jornada | 06.11.2021 | FK Bregalnica Štip | - | FK Skopje | 2:1 | |
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| 18. Jornada | 12.12.2021 | KF Shkëndija 79 | - | FK Skopje | 1:0 | ||||
| 20. Jornada | 20.02.2022 | FK AP Brera Strumica | - | FK Skopje | 5:0 | ||||
| 26. Jornada | 06.04.2022 | FK Skopje | - | KF Shkupi | 0:0 | ||||
| 27. Jornada | 10.04.2022 | FC Struga | - | FK Skopje | 1:0 | ||||
| 30. Jornada | 01.05.2022 | FK Borec | - | FK Skopje | 1:0 | ||||
| 31. Jornada | 04.05.2022 | FK Skopje | - | FK Pelister | 4:2 | ||||
| 32. Jornada | 08.05.2022 | FK Renova | - | FK Skopje | 2:0 | ||||
| 33. Jornada | 15.05.2022 | FK Skopje | - | FK Bregalnica Štip | 4:1 |
Macedonia del Norte