| 3. Jornada | 26.02.2022 | Armenio | - | Atlético San Miguel | 1:1 | ||||
| 4. Jornada | 05.03.2022 | Atlético San Miguel | - | Dock Sud | 0:1 | ||||
| 5. Jornada | 12.03.2022 | UAI Urquiza | - | Atlético San Miguel | 2:0 |  |
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| 6. Jornada | 20.03.2022 | Atlético San Miguel | - | Villa San Carlos | 2:1 | ||||
| 7. Jornada | 26.03.2022 | Defensores Unidos de Zárate | - | Atlético San Miguel | 2:1 | ||||
| 8. Jornada | 02.04.2022 | Atlético San Miguel | - | Talleres (RdE) | 0:1 | ||||
| 9. Jornada | 09.04.2022 | Deportivo Merlo | - | Atlético San Miguel | 2:0 | ||||
| 10. Jornada | 16.04.2022 | Atlético San Miguel | - | Colegiales de Munro | 0:1 | ||||
| 11. Jornada | 24.04.2022 | Acassuso | - | Atlético San Miguel | 2:1 | ||||
| 16. Jornada | 28.05.2022 | Atlético San Miguel | - | CA Los Andes | 1:1 |
Argentina