| 1. Jornada | 16.07.2022 | Tacuary | - | Guaireña FC | 0:0 | ||||
| 2. Jornada | 19.07.2022 | Guaireña FC | - | Sportivo Ameliano | 3:1 | ||||
| 3. Jornada | 24.07.2022 | Club Olimpia | - | Guaireña FC | 2:1 | ||||
| 4. Jornada | 29.07.2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
| 7. Jornada | 20.08.2022 | Sol de América | - | Guaireña FC | 2:0 | ||||
| 8. Jornada | 26.08.2022 | Guaireña FC | - | Club Nacional | 1:3 | ||||
| 11. Jornada | 15.09.2022 | Cerro Porteño | - | Guaireña FC | 2:2 |  |
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| 12. Jornada | 19.09.2022 | Guaireña FC | - | Tacuary | 1:0 | |
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| 13. Jornada | 23.09.2022 | Sportivo Ameliano | - | Guaireña FC | 2:0 | ||||
| 15. Jornada | 05.10.2022 | General Caballero DJLM | - | Guaireña FC | 0:0 |  |
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| 18. Jornada | 21.10.2022 | Guaireña FC | - | Sol de América | 0:0 | ||||
| 20. Jornada | 30.10.2022 | Guaireña FC | - | Guaraní | 1:0 | ||||
| 21. Jornada | 06.11.2022 | Libertad | - | Guaireña FC | 4:2 | ||||
| 22. Jornada | 12.11.2022 | Guaireña FC | - | Cerro Porteño | 1:3 | |
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