| 2. Jornada | 17.02.2022 | River Plate | - | Patronato de Paraná | 4:1 | ||||
| 3. Jornada | 21.02.2022 | Newell's Old Boys | - | River Plate | 0:2 | ||||
| 4. Jornada | 27.02.2022 | River Plate | - | Racing Club | 2:2 | ||||
| 5. Jornada | 05.03.2022 | San Lorenzo | - | River Plate | 0:1 |  |
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| 6. Jornada | 13.03.2022 | River Plate | - | Gimnasia de La Plata | 4:0 | |
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| 7. Jornada | 20.03.2022 | River Plate | - | Boca Juniors | 0:1 | ||||
| 11. Jornada | 21.04.2022 | Talleres de Córdoba | - | River Plate | 1:0 | |
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| 13. Jornada | 01.05.2022 | Sarmiento de Junín | - | River Plate | 0:7 | ||||
| 14. Jornada | 09.05.2022 | River Plate | - | Platense | 2:1 | |
Argentina
Portugal 
