| 1. Jornada | 17.07.2021 | Atlético San Miguel | - | UAI Urquiza | 0:1 | ||||
| 2. Jornada | 24.07.2021 | Talleres (RdE) | - | Atlético San Miguel | 1:1 | ||||
| 4. Jornada | 07.08.2021 | Atlético San Miguel | - | Deportivo Merlo | 1:0 |  |
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| 5. Jornada | 14.08.2021 | Flandria | - | Atlético San Miguel | 3:0 | ||||
| 6. Jornada | 21.08.2021 | Atlético San Miguel | - | Cañuelas | 0:2 | ||||
| 7. Jornada | 28.08.2021 | Acassuso | - | Atlético San Miguel | 4:1 | |
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| 8. Jornada | 04.09.2021 | Atlético San Miguel | - | Sacachispas | 3:1 |  |
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| 9. Jornada | 13.09.2021 | Justo José de Urquiza | - | Atlético San Miguel | 1:2 | ||||
| 10. Jornada | 18.09.2021 | Atlético San Miguel | - | Argentino de Quilmes | 1:1 | ||||
| 11. Jornada | 25.09.2021 | CA Los Andes | - | Atlético San Miguel | 0:0 | ||||
| 12. Jornada | 02.10.2021 | Atlético San Miguel | - | Colegiales de Munro | 0:2 | |
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| 13. Jornada | 09.10.2021 | Fénix | - | Atlético San Miguel | 1:2 | |
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| 15. Jornada | 24.10.2021 | Villa San Carlos | - | Atlético San Miguel | 4:2 | ||||
| 16. Jornada | 30.10.2021 | Atlético San Miguel | - | Armenio | 0:1 | ||||
| 17. Jornada | 06.11.2021 | Comunicaciones de Buenos Aires | - | Atlético San Miguel | 2:2 |
Argentina