| 3. Jornada | 02.02.2021 | Real Santander | - | Atlético FC | 2:2 | ||||
| 4. Jornada | 06.02.2021 | Barranquilla FC | - | Real Santander | 1:0 |  |
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| 5. Jornada | 12.02.2021 | Real Santander | - | Valledupar FC | 0:1 | |
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| 6. Jornada | 14.02.2021 | Llaneros FC | - | Real Santander | 0:0 | ||||
| 9. Jornada | 04.03.2021 | Real Santander | - | Orsomarso SC | 1:2 | |
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| 10. Jornada | 07.03.2021 | Real Santander | - | Boca Juniors de Cali | 0:1 |  |
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| 13. Jornada | 27.03.2021 | Bogotá FC | - | Real Santander | 1:4 |  |
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| 14. Jornada | 03.04.2021 | Real Santander | - | Fortaleza FC | 3:1 |
Colombia