| 3. Jornada | 31.07.2021 | Deportes Tolima | - | Alianza Petrolera | 1:1 | ||||
| 4. Jornada | 09.08.2021 | Atlético Junior | - | Deportes Tolima | 0:0 | ||||
| 5. Jornada | 14.08.2021 | Deportes Tolima | - | Deportivo Pasto | 1:0 |  |
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| 6. Jornada | 22.08.2021 | La Equidad | - | Deportes Tolima | 1:1 | ||||
| 18. Jornada | 08.11.2021 | Deportes Tolima | - | Millonarios | 3:2 | |
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| 19. Jornada | 15.11.2021 | Atlético Bucaramanga | - | Deportes Tolima | 1:1 | |
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| 20. Jornada | 21.11.2021 | Deportes Tolima | - | Deportes Quindío | 3:1 |
Colombia