| 2. Jornada | 24.03.2021 | Guayaquil SC | - | Cumbayá | 0:1 | ||||
| 4. Jornada | 07.04.2021 | Gualaceo SC | - | Guayaquil SC | 2:0 |  |
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| 5. Jornada | 15.04.2021 | Guayaquil SC | - | El Nacional | 2:1 | ||||
| 19. Jornada | 04.07.2021 | Atlético Porteño | - | Guayaquil SC | 4:1 | ||||
| 25. Jornada | 29.07.2021 | Guayaquil SC | - | Chacaritas FC | 0:0 | ||||
| 26. Jornada | 04.08.2021 | América de Quito | - | Guayaquil SC | 2:0 | ||||
| 27. Jornada | 12.08.2021 | Guayaquil SC | - | Atlético Santo Domingo | 0:1 | |
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| 29. Jornada | 26.08.2021 | Guayaquil SC | - | Gualaceo SC | 0:2 |
Ecuador