| 2. Jornada | 16.07.2016 | Cerro Porteño | - | Club Nacional | 1:1 | ||||
| 3. Jornada | 21.07.2016 | Club Nacional | - | Sol de América | 2:1 |  |
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| 4. Jornada | 26.07.2016 | Club Nacional | - | Sportivo Luqueño | 1:2 | |
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| 7. Jornada | 15.08.2016 | Guaraní | - | Club Nacional | 1:0 | ||||
| 8. Jornada | 20.08.2016 | Club Nacional | - | Club Olimpia | 3:4 | ||||
| 9. Jornada | 27.08.2016 | Club Rubio Ñu | - | Club Nacional | 0:0 | ||||
| 11. Jornada | 18.09.2016 | River Plate | - | Club Nacional | 2:3 | |
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| 13. Jornada | 03.10.2016 | Club Nacional | - | Cerro Porteño | 1:6 | ||||
| 16. Jornada | 30.10.2016 | Club Nacional | - | Libertad | 1:2 | ||||
| 18. Jornada | 21.11.2016 | Club Nacional | - | Guaraní | 1:1 | |
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| 19. Jornada | 27.11.2016 | Club Olimpia | - | Club Nacional | 2:1 | |
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| 20. Jornada | 04.12.2016 | Club Nacional | - | Club Rubio Ñu | 3:1 | |
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| 21. Jornada | 11.12.2016 | General Caballero ZC | - | Club Nacional | 1:2 | |
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| 22. Jornada | 18.12.2016 | Club Nacional | - | River Plate | 2:0 |
Paraguay