| 1. Jornada | 31.07.2021 | Ross County FC | - | St. Johnstone FC | 0:0 | ||||
| 2. Jornada | 08.08.2021 | St. Johnstone FC | - | Motherwell FC | 1:1 |  |
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| 3. Jornada | 22.08.2021 | St. Johnstone FC | - | Dundee United | 0:1 | ||||
| 4. Jornada | 29.08.2021 | St. Mirren FC | - | St. Johnstone FC | 0:0 | |
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| 5. Jornada | 11.09.2021 | St. Johnstone FC | - | Rangers FC | 1:2 | |
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| 7. Jornada | 26.09.2021 | Hibernian FC | - | St. Johnstone FC | 1:0 | |
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| 8. Jornada | 02.10.2021 | St. Johnstone FC | - | Dundee FC | 3:1 | |
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| 9. Jornada | 16.10.2021 | St. Johnstone FC | - | Livingston FC | 0:3 | |
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| 16. Jornada | 01.12.2021 | Dundee FC | - | St. Johnstone FC | 1:0 | ||||
| 18. Jornada | 11.12.2021 | St. Johnstone FC | - | Aberdeen FC | 0:1 | |
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| 14. Jornada | 15.12.2021 | Rangers FC | - | St. Johnstone FC | 2:0 | |
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| 19. Jornada | 18.12.2021 | Motherwell FC | - | St. Johnstone FC | 2:0 | ||||
| 20. Jornada | 26.12.2021 | St. Johnstone FC | - | Celtic FC | 1:3 | ||||
| 24. Jornada | 15.02.2022 | Aberdeen FC | - | St. Johnstone FC | 1:1 |
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