| 1. Jornada | 02.06.2021 | Albion | - | CA Cerro | 1:2 |  |
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| 3. Jornada | 17.06.2021 | Central Español | - | CA Cerro | 3:2 | ||||
| 4. Jornada | 25.06.2021 | CA Cerro | - | Atenas | 1:1 | ||||
| 5. Jornada | 01.07.2021 | Racing | - | CA Cerro | 0:0 | ||||
| 7. Jornada | 15.07.2021 | Juventud de Las Piedras | - | CA Cerro | 3:1 | ||||
| 12. Jornada | 17.09.2021 | CA Cerro | - | Albion | 1:0 | ||||
| 13. Jornada | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 14. Jornada | 29.09.2021 | CA Cerro | - | Central Español | 0:0 | ||||
| 15. Jornada | 04.10.2021 | Atenas | - | CA Cerro | 1:2 | ||||
| 16. Jornada | 14.10.2021 | CA Cerro | - | Racing | 1:0 | ||||
| 20. Jornada | 11.11.2021 | CA Cerro | - | Rampla Juniors | 1:2 | ||||
| 21. Jornada | 18.11.2021 | Danubio | - | CA Cerro | 0:0 |
Uruguay