| 1. Jornada | 25.07.2010 | Universitario de Sucre | - | Club San José | 2:2 |  |
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| 2. Jornada | 01.08.2010 | Club San José | - | Blooming | 2:0 | ||||
| 3. Jornada | 08.08.2010 | Jorge Wilstermann | - | Club San José | 1:3 | ||||
| 4. Jornada | 15.08.2010 | Club San José | - | The Strongest | 3:2 |  |
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| 6. Jornada | 28.08.2010 | Club San José | - | Real Potosí | 2:3 | |
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| 7. Jornada | 05.09.2010 | Oriente Petrolero | - | Club San José | 2:1 | ||||
| 8. Jornada | 11.09.2010 | Club San José | - | Club Aurora | 3:3 | |
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| 12. Jornada | 03.10.2010 | Club San José | - | Universitario de Sucre | 2:1 | |
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| 15. Jornada | 17.10.2010 | The Strongest | - | Club San José | 1:2 | ||||
| 16. Jornada | 24.10.2010 | Club San José | - | CD Guabirá | 5:1 | ||||
| 13. Jornada | 28.10.2010 | Blooming | - | Club San José | 2:2 | ||||
| 18. Jornada | 31.10.2010 | Club San José | - | Oriente Petrolero | 0:3 | ||||
| 17. Jornada | 04.11.2010 | Real Potosí | - | Club San José | 1:3 | |
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| 20. Jornada | 14.11.2010 | Club San José | - | Bolívar | 0:1 | ||||
| 21. Jornada | 21.11.2010 | Real Mamoré | - | Club San José | 3:0 | |
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| 22. Jornada | 28.11.2010 | Club San José | - | La Paz FC | 1:0 |
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