| 1. Jornada | 19.07.2021 | Libertad | - | Guaireña FC | 0:0 | ||||
| 2. Jornada | 26.07.2021 | Cerro Porteño | - | Libertad | 1:1 | ||||
| 3. Jornada | 01.08.2021 | Libertad | - | Sol de América | 1:1 | ||||
| 4. Jornada | 07.08.2021 | Club Nacional | - | Libertad | 1:0 | ||||
| 6. Jornada | 24.08.2021 | Guaraní | - | Libertad | 2:2 |  |
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| 7. Jornada | 29.08.2021 | Libertad | - | Sportivo Luqueño | 5:0 | |
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| 11. Jornada | 04.10.2021 | Libertad | - | Cerro Porteño | 0:2 |  |
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| 12. Jornada | 17.10.2021 | Sol de América | - | Libertad | 0:4 | |
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| 13. Jornada | 25.10.2021 | Libertad | - | Club Nacional | 1:2 | ||||
| 14. Jornada | 30.10.2021 | 12 de Octubre de Itauguá | - | Libertad | 0:1 | ||||
| 15. Jornada | 07.11.2021 | Libertad | - | Guaraní | 2:0 | |
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| 16. Jornada | 20.11.2021 | Sportivo Luqueño | - | Libertad | 2:2 | ||||
| 17. Jornada | 26.11.2021 | Club Olimpia | - | Libertad | 2:3 | |
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| 18. Jornada | 03.12.2021 | Libertad | - | River Plate | 5:0 | |
Paraguay