| 7. Jornada | 11.09.2021 | Paris FC | - | Guingamp | 0:1 | ||||
| 8. Jornada | 18.09.2021 | Chamois Niortais | - | Guingamp | 2:0 | ||||
| 9. Jornada | 21.09.2021 | Guingamp | - | FC Sochaux | 1:2 | ||||
| 11. Jornada | 02.10.2021 | Guingamp | - | Rodez AF | 2:1 | ||||
| 12. Jornada | 16.10.2021 | AS Nancy Lorraine | - | Guingamp | 2:1 |  |
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| 13. Jornada | 23.10.2021 | Guingamp | - | Nîmes Olympique | 3:1 | ||||
| 18. Jornada | 11.12.2021 | Caen | - | Guingamp | 2:0 | ||||
| 20. Jornada | 08.01.2022 | Valenciennes FC | - | Guingamp | 1:1 | ||||
| 22. Jornada | 22.01.2022 | Amiens SC | - | Guingamp | 3:0 | ||||
| 29. Jornada | 15.03.2022 | Rodez AF | - | Guingamp | 1:1 | ||||
| 34. Jornada | 19.04.2022 | Guingamp | - | Pau FC | 3:0 |
Francia