| 2. Jornada | 25.07.2021 | Rosario Central | - | Vélez Sarsfield | 1:0 | ||||
| 3. Jornada | 29.07.2021 | Gimnasia de La Plata | - | Rosario Central | 1:0 | ||||
| 4. Jornada | 03.08.2021 | Rosario Central | - | Aldosivi | 1:2 | ||||
| 5. Jornada | 07.08.2021 | Sarmiento de Junín | - | Rosario Central | 1:0 | ||||
| 6. Jornada | 15.08.2021 | Rosario Central | - | Independiente | 1:2 | ||||
| 8. Jornada | 25.08.2021 | Rosario Central | - | Arsenal de Sarandí | 4:0 | ||||
| 9. Jornada | 29.08.2021 | Central Córdoba SdE | - | Rosario Central | 2:4 | ||||
| 12. Jornada | 20.09.2021 | Rosario Central | - | San Lorenzo | 1:0 |  |
 |
||
| 13. Jornada | 25.09.2021 | Talleres de Córdoba | - | Rosario Central | 4:1 | ||||
| 14. Jornada | 03.10.2021 | Rosario Central | - | Argentinos Juniors | 0:1 | ||||
| 17. Jornada | 19.10.2021 | Platense | - | Rosario Central | 1:1 | ||||
| 18. Jornada | 24.10.2021 | Rosario Central | - | Racing Club | 2:1 | ||||
| 21. Jornada | 20.11.2021 | Rosario Central | - | Atlético Tucumán | 3:1 | ||||
| 24. Jornada | 05.12.2021 | CA Lanús | - | Rosario Central | 2:2 | ||||
| 25. Jornada | 11.12.2021 | Rosario Central | - | Huracán | 1:4 | |
México
Argentina