| 15. Jornada | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 |  |
|||
| 19. Jornada | 02.11.2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 | ||||
| 20. Jornada | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | |
|||
| 21. Jornada | 18.11.2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | ||||
| 22. Jornada | 24.11.2021 | Defensor Sporting | - | Danubio | 0:1 |
Uruguay