| 4. Jornada | 03.08.2021 | Rosario Central | - | Aldosivi | 1:2 | ||||
| 7. Jornada | 22.08.2021 | Newell's Old Boys | - | Rosario Central | 1:1 | ||||
| 8. Jornada | 25.08.2021 | Rosario Central | - | Arsenal de Sarandí | 4:0 |  |
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| 9. Jornada | 29.08.2021 | Central Córdoba SdE | - | Rosario Central | 2:4 | ||||
| 10. Jornada | 05.09.2021 | Rosario Central | - | Boca Juniors | 1:2 | ||||
| 11. Jornada | 15.09.2021 | Banfield | - | Rosario Central | 1:2 | ||||
| 12. Jornada | 20.09.2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
| 16. Jornada | 15.10.2021 | Rosario Central | - | Patronato de Paraná | 3:2 | ||||
| 17. Jornada | 19.10.2021 | Platense | - | Rosario Central | 1:1 | |
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| 18. Jornada | 24.10.2021 | Rosario Central | - | Racing Club | 2:1 | ||||
| 19. Jornada | 31.10.2021 | Unión de Santa Fe | - | Rosario Central | 3:1 | ||||
| 20. Jornada | 05.11.2021 | Defensa y Justicia | - | Rosario Central | 3:0 | ||||
| 21. Jornada | 20.11.2021 | Rosario Central | - | Atlético Tucumán | 3:1 | ||||
| 22. Jornada | 25.11.2021 | Colón de Santa Fe | - | Rosario Central | 1:4 | ||||
| 25. Jornada | 11.12.2021 | Rosario Central | - | Huracán | 1:4 |
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