| 3. Jornada | 15.02.2021 | Club Olimpia | - | Guaireña FC | 0:0 | ||||
| 4. Jornada | 21.02.2021 | Cerro Porteño | - | Guaireña FC | 2:2 | ||||
| 2. Jornada | 24.02.2021 | Guaireña FC | - | Libertad | 1:0 | ||||
| 6. Jornada | 05.03.2021 | River Plate | - | Guaireña FC | 0:1 |  |
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| 9. Jornada | 22.03.2021 | Guaireña FC | - | Sol de América | 2:2 | ||||
| 10. Jornada | 04.04.2021 | Guaireña FC | - | Sportivo Luqueño | 3:0 | ||||
| 11. Jornada | 12.04.2021 | Libertad | - | Guaireña FC | 2:1 | ||||
| 12. Jornada | 17.04.2021 | Guaireña FC | - | Club Olimpia | 1:2 | ||||
| 13. Jornada | 25.04.2021 | Guaireña FC | - | Cerro Porteño | 0:1 | ||||
| 15. Jornada | 10.05.2021 | Guaireña FC | - | River Plate | 0:0 | ||||
| 16. Jornada | 16.05.2021 | 12 de Octubre de Itauguá | - | Guaireña FC | 1:1 |
Paraguay