| 1. Jornada | 13.09.2021 | Liverpool | - | Deportivo Maldonado | 1:0 | ||||
| 2. Jornada | 19.09.2021 | Liverpool | - | River Plate | 3:1 | ||||
| 3. Jornada | 25.09.2021 | Cerro Largo | - | Liverpool | 3:0 |  |
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| 5. Jornada | 10.10.2021 | Sud América | - | Liverpool | 0:1 | |
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| 6. Jornada | 16.10.2021 | Liverpool | - | Plaza Colonia | 0:1 | |
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| 8. Jornada | 24.10.2021 | Liverpool | - | Boston River | 2:2 | ||||
| 9. Jornada | 30.10.2021 | Montevideo Wanderers | - | Liverpool | 1:0 | |
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| 10. Jornada | 03.11.2021 | Liverpool | - | Rentistas | 0:1 | |
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| 11. Jornada | 07.11.2021 | Peñarol | - | Liverpool | 1:0 | ||||
| 12. Jornada | 13.11.2021 | Liverpool | - | Montevideo City Torque | 1:3 | ||||
| 13. Jornada | 19.11.2021 | Villa Española | - | Liverpool | 0:3 | ||||
| 15. Jornada | 06.12.2021 | Cerrito | - | Liverpool | 2:1 |
Uruguay