| 1. Jornada | 24.01.2021 | Junior Managua | - | Managua FC | 1:3 |  |
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| 2. Jornada | 28.01.2021 | Managua FC | - | Club Deportivo Ocotal | 3:0 | |
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| 3. Jornada | 31.01.2021 | Chinandega | - | Managua FC | 1:1 | ||||
| 4. Jornada | 04.02.2021 | Managua FC | - | Real Madriz | 4:1 | |
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| 5. Jornada | 07.02.2021 | Juventus Managua | - | Managua FC | 0:5 | |
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| 6. Jornada | 11.02.2021 | Managua FC | - | ART Municipal Jalapa | 5:2 | |
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| 7. Jornada | 14.02.2021 | CD Walter Ferretti | - | Managua FC | 2:1 | ||||
| 8. Jornada | 18.02.2021 | Managua FC | - | Diriangén FC | 1:3 | |
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| 9. Jornada | 01.03.2021 | Real Estelí FC | - | Managua FC | 1:1 | ||||
| 11. Jornada | 15.03.2021 | Club Deportivo Ocotal | - | Managua FC | 1:0 | ||||
| 12. Jornada | 01.04.2021 | Managua FC | - | Chinandega | 3:1 | ||||
| 13. Jornada | 15.04.2021 | Real Madriz | - | Managua FC | 1:0 | ||||
| 14. Jornada | 19.04.2021 | Managua FC | - | Juventus Managua | 4:1 | ||||
| 15. Jornada | 26.04.2021 | ART Municipal Jalapa | - | Managua FC | 2:2 | |
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| 16. Jornada | 29.04.2021 | Managua FC | - | CD Walter Ferretti | 3:1 | |
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| 17. Jornada | 02.05.2021 | Diriangén FC | - | Managua FC | 4:1 | ||||
| 18. Jornada | 07.05.2021 | Managua FC | - | Real Estelí FC | 1:0 |
Brasil