| 8. Jornada | 21.08.2021 | Mannucci | - | FBC Melgar | 1:2 | ||||
| 9. Jornada | 28.08.2021 | Alianza Atlético | - | Mannucci | 2:0 |  |
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| 10. Jornada | 12.09.2021 | Mannucci | - | Universidad Técnica | 1:3 | |
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| 11. Jornada | 18.09.2021 | Mannucci | - | Alianza Universidad | 1:1 |  |
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| 13. Jornada | 25.09.2021 | Mannucci | - | Cienciano | 1:3 | ||||
| 14. Jornada | 01.10.2021 | Ayacucho FC | - | Mannucci | 3:2 | ||||
| 15. Jornada | 16.10.2021 | Mannucci | - | Alianza Lima | 0:1 | |
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| 17. Jornada | 30.10.2021 | Mannucci | - | Academia Cantolao | 1:0 |
Uruguay