| 4. Jornada | 30.07.2021 | Rosario Central II | - | Aldosivi II | 4:1 |  |
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| 5. Jornada | 06.08.2021 | Sarmiento de Junín II | - | Rosario Central II | 2:2 | ||||
| 6. Jornada | 13.08.2021 | Rosario Central II | - | Independiente II | 3:1 | ||||
| 7. Jornada | 20.08.2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 10. Jornada | 03.09.2021 | Rosario Central II | - | Boca Juniors II | 1:3 | ||||
| 11. Jornada | 14.09.2021 | Banfield II | - | Rosario Central II | 1:3 | ||||
| 12. Jornada | 17.09.2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 13. Jornada | 24.09.2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 15. Jornada | 08.10.2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 20. Jornada | 05.11.2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 22. Jornada | 24.11.2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 |
Argentina