| 1. Jornada | 18.09.2021 | CF Pachuca [] | - | Deportivo Toluca [] | 5:0 | ||||
| 2. Jornada | 25.09.2021 | Cruz Azul [] | - | CF Pachuca [] | 3:6 | ||||
| 3. Jornada | 02.10.2021 | CF Pachuca [] | - | Puebla FC [] | 4:0 | ||||
| 4. Jornada | 09.10.2021 | Pumas UNAM [] | - | CF Pachuca [] | 1:1 | ||||
| 5. Jornada | 16.10.2021 | CF Pachuca [] | - | FC Juárez [] | 7:0 | ||||
| 8. Jornada | 06.11.2021 | CF Pachuca [] | - | CF América [] | 5:3 | ||||
| 10. Jornada | 20.11.2021 | CF Pachuca [] | - | Gallos Blancos [] | 2:1 |
México