| 1. Jornada | 24.07.2021 | CF Pachuca [Sub 18] | - | Club León [Sub 18] | 5:1 | ||||
| 2. Jornada | 31.07.2021 | Club León [Sub 18] | - | Club Tijuana [Sub 18] | 2:1 | ||||
| 4. Jornada | 14.08.2021 | Club León [Sub 18] | - | Mazatlán FC [Sub 18] | 1:1 | ||||
| 5. Jornada | 18.08.2021 | Deportivo Guadalajara [Sub 18] | - | Club León [Sub 18] | 1:1 | ||||
| 9. Jornada | 18.09.2021 | Club León [Sub 18] | - | FC Juárez [Sub 18] | 2:1 | ||||
| 13. Jornada | 16.10.2021 | CF Monterrey [Sub 18] | - | Club León [Sub 18] | 0:1 | ||||
| 14. Jornada | 20.10.2021 | Club León [Sub 18] | - | Pumas UNAM [Sub 18] | 2:1 | ||||
| 15. Jornada | 23.10.2021 | Puebla FC [Sub 18] | - | Club León [Sub 18] | 2:1 |  |
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| 17. Jornada | 06.11.2021 | Club León [Sub 18] | - | Club Necaxa [Sub 18] | 3:2 |
México