| 14. Jornada | 28.11.2021 | Deportivo | - | Bilbao Athletic | 1:1 | ||||
| 18. Jornada | 09.01.2022 | CD Calahorra | - | Bilbao Athletic | 1:1 |  |
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| 19. Jornada | 22.01.2022 | Bilbao Athletic | - | Extremadura UD | 3:0 | ||||
| 20. Jornada | 25.01.2022 | Bilbao Athletic | - | CyD Leonesa | 1:2 | |
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| 25. Jornada | 25.02.2022 | Bilbao Athletic | - | Valladolid B | 3:0 | ||||
| 27. Jornada | 13.03.2022 | Bilbao Athletic | - | Inter de Madrid | 1:0 | ||||
| 28. Jornada | 20.03.2022 | CF Talavera | - | Bilbao Athletic | 4:0 |  |
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| 29. Jornada | 27.03.2022 | Bilbao Athletic | - | CD Tudelano | 1:0 | ||||
| 31. Jornada | 10.04.2022 | Bilbao Athletic | - | Deportivo | 1:1 | ||||
| 32. Jornada | 16.04.2022 | Real Unión | - | Bilbao Athletic | 1:1 | ||||
| 33. Jornada | 24.04.2022 | Bilbao Athletic | - | SD Logroñés | 1:0 | |
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| 34. Jornada | 30.04.2022 | CD Badajoz | - | Bilbao Athletic | 1:0 | ||||
| 35. Jornada | 08.05.2022 | Bilbao Athletic | - | CD Calahorra | 1:3 | ||||
| 36. Jornada | 15.05.2022 | Racing de Ferrol | - | Bilbao Athletic | 1:1 | ||||
| 37. Jornada | 21.05.2022 | Bilbao Athletic | - | Real Racing | 2:1 | |
España