| 1. Jornada | 18.07.2021 | Club Olimpia | - | River Plate | 1:3 | ||||
| 2. Jornada | 25.07.2021 | Guaireña FC | - | River Plate | 1:2 |  |
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| 3. Jornada | 31.07.2021 | River Plate | - | Cerro Porteño | 0:0 | ||||
| 4. Jornada | 09.08.2021 | Sol de América | - | River Plate | 1:0 | ||||
| 5. Jornada | 14.08.2021 | River Plate | - | Club Nacional | 1:0 | ||||
| 6. Jornada | 22.08.2021 | 12 de Octubre de Itauguá | - | River Plate | 2:2 | |
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| 7. Jornada | 30.08.2021 | River Plate | - | Guaraní | 1:5 |  |
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| 10. Jornada | 27.09.2021 | River Plate | - | Club Olimpia | 1:2 | |
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| 11. Jornada | 03.10.2021 | River Plate | - | Guaireña FC | 1:1 | |
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| 12. Jornada | 19.10.2021 | Cerro Porteño | - | River Plate | 2:0 | ||||
| 13. Jornada | 23.10.2021 | River Plate | - | Sol de América | 0:2 | ||||
| 14. Jornada | 30.10.2021 | Club Nacional | - | River Plate | 1:1 | ||||
| 15. Jornada | 05.11.2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | |
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| 16. Jornada | 20.11.2021 | Guaraní | - | River Plate | 2:1 | ||||
| 17. Jornada | 26.11.2021 | River Plate | - | Sportivo Luqueño | 0:0 | ||||
| 18. Jornada | 03.12.2021 | Libertad | - | River Plate | 5:0 |
Paraguay