| 2. Jornada | 15.01.2022 | Atlas Guadalajara [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 | ||||
| 3. Jornada | 20.01.2022 | Atlético San Luis [Sub 20] | - | FC Juárez [Sub 20] | 7:1 |  |
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| 4. Jornada | 05.02.2022 | CF América [Sub 20] | - | Atlético San Luis [Sub 20] | 0:1 | ||||
| 14. Jornada | 15.04.2022 | Club Necaxa [Sub 20] | - | Atlético San Luis [Sub 20] | 3:0 | ||||
| 15. Jornada | 20.04.2022 | Atlético San Luis [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | ||||
| 16. Jornada | 24.04.2022 | Cruz Azul [Sub 20] | - | Atlético San Luis [Sub 20] | 2:2 | ||||
| 17. Jornada | 01.05.2022 | Atlético San Luis [Sub 20] | - | Santos Laguna [Sub 20] | 2:2 |
México