| 1. Jornada | 10.01.2021 | CF América | - | Atlético San Luis | 2:1 | ||||
| 2. Jornada | 16.01.2021 | Club Necaxa | - | Atlético San Luis | 1:0 | ||||
| 4. Jornada | 02.02.2021 | Club León | - | Atlético San Luis | 3:1 | ||||
| 5. Jornada | 05.02.2021 | Atlético San Luis | - | Club Tijuana | 2:2 |  |
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| 6. Jornada | 13.02.2021 | Mazatlán FC | - | Atlético San Luis | 0:3 | ||||
| 7. Jornada | 19.02.2021 | Atlético San Luis | - | Santos Laguna | 1:0 | ||||
| 8. Jornada | 26.02.2021 | Atlético San Luis | - | UANL Tigres | 2:2 | ||||
| 9. Jornada | 03.03.2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 | ||||
| 10. Jornada | 06.03.2021 | Atlético San Luis | - | Deportivo Toluca | 0:0 | ||||
| 12. Jornada | 21.03.2021 | Atlético San Luis | - | Pumas UNAM | 0:1 |  |
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| 15. Jornada | 18.04.2021 | Atlético San Luis | - | Puebla FC | 1:4 | |
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| 16. Jornada | 25.04.2021 | Cruz Azul | - | Atlético San Luis | 3:2 |
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