| 2. Jornada | 15.01.2022 | Club Necaxa | - | CF Monterrey | 0:4 | ||||
| 5. Jornada | 13.02.2022 | Cruz Azul | - | Club Necaxa | 1:2 | ||||
| 6. Jornada | 19.02.2022 | Club Tijuana | - | Club Necaxa | 1:1 |  |
|||
| 7. Jornada | 26.02.2022 | Club Necaxa | - | Club León | 0:1 | ||||
| 8. Jornada | 02.03.2022 | Mazatlán FC | - | Club Necaxa | 0:0 | ||||
| 9. Jornada | 05.03.2022 | Club Necaxa | - | Deportivo Toluca | 0:1 | ||||
| 10. Jornada | 12.03.2022 | Club Necaxa | - | Gallos Blancos | 1:0 | ||||
| 11. Jornada | 20.03.2022 | Pumas UNAM | - | Club Necaxa | 1:3 | ||||
| 12. Jornada | 03.04.2022 | Club Necaxa | - | CF América | 0:1 |
México