| 1. Jornada | 04.02.2022 | Universitario de Vinto | - | Real Tomayapo | 1:1 | ||||
| 2. Jornada | 13.02.2022 | Real Tomayapo | - | Independiente Petrolero | 1:1 | ||||
| 3. Jornada | 19.02.2022 | Always Ready | - | Real Tomayapo | 0:1 | ||||
| 4. Jornada | 26.02.2022 | Real Tomayapo | - | Royal Pari | 1:0 |  |
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| 5. Jornada | 06.03.2022 | Real Tomayapo | - | Bolívar | 1:1 | ||||
| 6. Jornada | 13.03.2022 | Nacional Potosí | - | Real Tomayapo | 5:0 |  |
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| 7. Jornada | 02.04.2022 | Jorge Wilstermann | - | Real Tomayapo | 1:2 | ||||
| 8. Jornada | 10.04.2022 | Real Tomayapo | - | Blooming | 1:2 | |
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| 9. Jornada | 16.04.2022 | Real Tomayapo | - | Universitario de Vinto | 0:1 |  |
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| 11. Jornada | 23.04.2022 | Real Tomayapo | - | Always Ready | 1:1 | |
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| 12. Jornada | 01.05.2022 | Royal Pari | - | Real Tomayapo | 6:1 | ||||
| 13. Jornada | 07.05.2022 | Real Tomayapo | - | Nacional Potosí | 1:0 | |
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| 15. Jornada | 15.05.2022 | Real Tomayapo | - | Jorge Wilstermann | 1:1 | |
Uruguay