| 1. Jornada | 25.07.2010 | Universitario de Sucre | - | Club San José | 2:2 |  |
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| 3. Jornada | 08.08.2010 | Jorge Wilstermann | - | Club San José | 1:3 | ||||
| 4. Jornada | 15.08.2010 | Club San José | - | The Strongest | 3:2 |  |
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| 5. Jornada | 22.08.2010 | CD Guabirá | - | Club San José | 3:1 | ||||
| 7. Jornada | 05.09.2010 | Oriente Petrolero | - | Club San José | 2:1 | |
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| 8. Jornada | 11.09.2010 | Club San José | - | Club Aurora | 3:3 |  |
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| 9. Jornada | 12.09.2010 | Bolívar | - | Club San José | 0:0 | ||||
| 10. Jornada | 18.09.2010 | Club San José | - | Real Mamoré | 1:0 | ||||
| 11. Jornada | 25.09.2010 | La Paz FC | - | Club San José | 4:3 | |
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| 12. Jornada | 03.10.2010 | Club San José | - | Universitario de Sucre | 2:1 | |
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| 13. Jornada | 28.10.2010 | Blooming | - | Club San José | 2:2 | |
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| 17. Jornada | 04.11.2010 | Real Potosí | - | Club San José | 1:3 | |
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| 19. Jornada | 07.11.2010 | Club Aurora | - | Club San José | 4:1 | |
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| 20. Jornada | 14.11.2010 | Club San José | - | Bolívar | 0:1 |  |
Bolivia