| 5. Jornada | 05.02.2022 | Nueva Concepción | - | Cobán Imperial | 1:2 |  |
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| 9. Jornada | 27.02.2022 | Cobán Imperial | - | Achuapa | 0:1 | ||||
| 10. Jornada | 02.03.2022 | Santa Lucía | - | Cobán Imperial | 2:1 | |
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| 11. Jornada | 06.03.2022 | Cobán Imperial | - | Deportivo Guastatoya | 0:0 | ||||
| 14. Jornada | 26.03.2022 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 15. Jornada | 03.04.2022 | Xelaju MC | - | Cobán Imperial | 2:2 | |
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| 22. Jornada | 08.05.2022 | Deportivo Guastatoya | - | Cobán Imperial | 4:0 |
Guatemala