| 1. Jornada | 10.01.2016 | CF América | - | Puebla FC | 0:0 | ||||
| 2. Jornada | 18.01.2016 | Puebla FC | - | CF Monterrey | 1:3 |  |
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| 3. Jornada | 24.01.2016 | Pumas UNAM | - | Puebla FC | 0:1 | ||||
| 4. Jornada | 31.01.2016 | Deportivo Toluca | - | Puebla FC | 1:1 | ||||
| 7. Jornada | 22.02.2016 | Puebla FC | - | Dorados de Sinaloa | 3:2 | ||||
| 8. Jornada | 28.02.2016 | Santos Laguna | - | Puebla FC | 1:1 | ||||
| 9. Jornada | 07.03.2016 | Puebla FC | - | CD Veracruz | 1:1 | ||||
| 10. Jornada | 13.03.2016 | Cruz Azul | - | Puebla FC | 1:1 | |
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| 11. Jornada | 21.03.2016 | Puebla FC | - | UANL Tigres | 0:0 | |
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| 12. Jornada | 03.04.2016 | Monarcas Morelia | - | Puebla FC | 2:0 | ||||
| 13. Jornada | 11.04.2016 | Puebla FC | - | Deportivo Guadalajara | 0:3 | ||||
| 14. Jornada | 17.04.2016 | Club León | - | Puebla FC | 4:1 | ||||
| 15. Jornada | 25.04.2016 | Puebla FC | - | Chiapas FC | 2:1 | ||||
| 16. Jornada | 30.04.2016 | Club Tijuana | - | Puebla FC | 0:0 | ||||
| 17. Jornada | 09.05.2016 | Puebla FC | - | Gallos Blancos | 3:1 |  |
México