| 2. Jornada | 13.03.2021 | Jorge Wilstermann | - | Nacional Potosí | 1:2 | ||||
| 1. Jornada | 28.03.2021 | Real Santa Cruz | - | Jorge Wilstermann | 0:2 | ||||
| 3. Jornada | 04.04.2021 | Oriente Petrolero | - | Jorge Wilstermann | 4:2 | ||||
| 4. Jornada | 11.04.2021 | Jorge Wilstermann | - | The Strongest | 0:3 | ||||
| 6. Jornada | 03.05.2021 | Atlético Palmaflor | - | Jorge Wilstermann | 3:1 |  |
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| 8. Jornada | 10.07.2021 | Royal Pari | - | Jorge Wilstermann | 3:2 | ||||
| 9. Jornada | 16.07.2021 | Jorge Wilstermann | - | Real Potosí | 3:1 | ||||
| 10. Jornada | 22.07.2021 | CD Guabirá | - | Jorge Wilstermann | 3:2 | ||||
| 14. Jornada | 08.08.2021 | Real Tomayapo | - | Jorge Wilstermann | 1:2 | |
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| 17. Jornada | 22.08.2021 | Nacional Potosí | - | Jorge Wilstermann | 0:1 | ||||
| 24. Jornada | 27.10.2021 | Real Potosí | - | Jorge Wilstermann | 2:2 |
Bolivia