| 13. Jornada | 28.11.2021 | Southampton Sub-21 | - | West Bromwich Albion Sub-21 | 3:1 |  |
|||
| 15. Jornada | 17.12.2021 | Norwich City Sub-21 | - | Southampton Sub-21 | 4:3 | ||||
| 17. Jornada | 17.01.2022 | Southampton Sub-21 | - | Fulham Sub-21 | 2:1 | ||||
| 18. Jornada | 23.01.2022 | Southampton Sub-21 | - | Middlesbrough Sub-21 | 1:0 | ||||
| 19. Jornada | 07.02.2022 | West Bromwich Albion Sub-21 | - | Southampton Sub-21 | 0:1 | |
|||
| 20. Jornada | 21.02.2022 | Southampton Sub-21 | - | Birmingham City U23 | 2:3 | |
|||
| 21. Jornada | 26.02.2022 | Southampton Sub-21 | - | Nottingham Forest U23 | 4:2 | |
|||
| 22. Jornada | 11.03.2022 | Aston Villa Sub-21 | - | Southampton Sub-21 | 2:2 |  |
|||
| 23. Jornada | 20.03.2022 | Southampton Sub-21 | - | Reading Sub-21 | 2:1 | |
|||
| 16. Jornada | 25.03.2022 | Southampton Sub-21 | - | Wolverhampton Wanderers Sub-21 | 2:4 | |
|||
| 24. Jornada | 02.04.2022 | Burnley FC U23 | - | Southampton Sub-21 | 2:1 | ||||
| 25. Jornada | 25.04.2022 | Newcastle United Sub-21 | - | Southampton Sub-21 | 2:4 | ||||
| 26. Jornada | 01.05.2022 | Southampton Sub-21 | - | Sunderland Sub-21 | 1:0 |
Inglaterra