| 10. Jornada | 30.10.2021 | Watford FC | - | Southampton | 0:1 | ||||
| 11. Jornada | 05.11.2021 | Southampton | - | Aston Villa | 1:0 | ||||
| 12. Jornada | 20.11.2021 | Norwich City | - | Southampton | 2:1 | ||||
| 13. Jornada | 27.11.2021 | Liverpool | - | Southampton | 4:0 | ||||
| 14. Jornada | 01.12.2021 | Southampton | - | Leicester City | 2:2 | ||||
| 15. Jornada | 04.12.2021 | Southampton | - | Brighton & Hove Albion | 1:1 | ||||
| 16. Jornada | 11.12.2021 | Arsenal | - | Southampton | 3:0 | ||||
| 17. Jornada | 15.12.2021 | Crystal Palace | - | Southampton | 2:2 |  |
|||
| 18. Jornada | 11.01.2022 | Southampton | - | Brentford FC | 4:1 | ||||
| 22. Jornada | 15.01.2022 | Wolverhampton Wanderers | - | Southampton | 3:1 | |
|||
| 23. Jornada | 22.01.2022 | Southampton | - | Manchester City | 1:1 | ||||
| 33. Jornada | 16.04.2022 | Southampton | - | Arsenal | 1:0 | ||||
| 30. Jornada | 21.04.2022 | Burnley FC | - | Southampton | 2:0 | ||||
| 37. Jornada | 17.05.2022 | Southampton | - | Liverpool | 1:2 | ||||
| 38. Jornada | 22.05.2022 | Leicester City | - | Southampton | 4:1 |
Brasil
Serbia